Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 3/20 | 0.47 |
| ▸ | CES1 | P23141 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5463394 | 1.00 | PTGS2 (0.49) | PTGS2CES2CES1ATMDRD4 | |
| SCHEMBL2045803 | 0.91 | DRD4 (0.48) | ATMDRD4DRD2GAAPPARA | |
| SCHEMBL2045805 | 0.91 | DRD4 (0.48) | ATMDRD4DRD2GAAPPARA | |
| SCHEMBL10040989 | 0.90 | SMN1; SMN2 (0.46) | PTGS2CES2CES1DRD4DRD2 | |
| SCHEMBL5461220 | 0.89 | ATM (0.48) | CES2CES1ATMDRD4DRD2 | |
| SCHEMBL5461219 | 0.89 | ATM (0.48) | CES2CES1ATMDRD4DRD2 | |
| SCHEMBL2046347 | 0.87 | DRD4 (0.50) | ATMDRD4DRD2PPARAGSK3B | |
| SCHEMBL2046346 | 0.87 | DRD4 (0.50) | ATMDRD4DRD2PPARAGSK3B | |
| SCHEMBL11257002 | 0.84 | DRD4 (0.47) | ATMDRD4DRD2PPARAGSK3B | |
| SCHEMBL11256999 | 0.84 | DRD4 (0.47) | ATMDRD4DRD2PPARAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420679-B2 | Aminothiazole derivatives and their use as CRF receptor ligands | SANOFI (FR) | 2013-04-16 | — | — | US | disclosed |
| EP-1200419-B1 | AMINOTHIAZOLE DERIVATIVES AND THEIR USE AS CRF RECEPTOR LIGANDS | SANOFI SYNTHELABO (FR) | 2004-04-14 | — | — | EP | disclosed |
| US-6586456-B1 | Corticotropin releasing factor (CRF) antagonists such as (4-(2-chloro-4-methoxy-5-methylphenyl)-5-methylthiazol-2-yl)(( (1-(3-fluoro-4-methylphenyl)-2-methoxyethyl))prop-2-ynylamine, prepared by alkylation with propagyl bromide | SANOFI-SYNTHELABO (FR) | 2003-07-01 | — | — | US | disclosed |