Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.43 |
| ▸ | PRKDC | P78527 | 6/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | XRCC6 | P12956 | 1/20 | 0.39 |
| ▸ | XRCC5 | P13010 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610914 | 0.89 | ALDH1A1 (0.42) | PIK3CDKDM4EKMT2ALMNAMAPT | |
| SCHEMBL6611419 | 0.88 | ALDH1A1 (0.47) | HTTKDM4EKMT2ALMNAMAPT | |
| SCHEMBL6612726 | 0.84 | PIK3CB (0.44) | PIK3CDPRKDCPIK3CAKDM4EKMT2A | |
| SCHEMBL6611735 | 0.80 | PIK3CD (0.42) | PIK3CDPRKDCPIK3CAHTTKDM4E | |
| SCHEMBL6611302 | 0.80 | GAA (0.43) | PIK3CDPRKDCPIK3CAKMT2AMAPT | |
| SCHEMBL21487020 | 0.73 | MAPT (0.37) | KDM4EMAPTALDH1A1HSD17B10ADORA2A | |
| SCHEMBL21487550 | 0.73 | HCRTR1 (0.36) | KDM4ELMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL6172641 | 0.73 | TP53 (0.61) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6612197 | 0.73 | PIK3CD (0.34) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22439098 | 0.72 | NQO2 (0.49) | KDM4EMAPTSMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261605-B1 | BENZOXAZOLE DERIVATIVES AS TNF AND PDE IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2004-11-10 | — | — | EP | disclosed |
| EP-1261605-A1 | BENZOXAZOLE DERIVATIVES AS TNF AND PDE IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-04 | — | — | EP | disclosed |
| US-6403791-B1 | TREATMENT OF INFLAMMATORY DISEASES OR AUTOIMMUNE DISEASES IN HUMANS OR ANIMALS | DARWIN DISCOVERY, LTD. (GB) | 2002-06-11 | — | — | US | disclosed |
| WO-2001058896-A1 | BENZOXAZOLE DERIVATIVES AS TNF AND PDE IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | disclosed |