Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.50 |
| ▸ | HPGD | P15428 | 8/20 | 0.50 |
| ▸ | LMNA | P02545 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5841833 | 0.88 | MAPT (0.53) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL6614770 | 0.85 | MAPT (0.48) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL6611824 | 0.84 | NPY5R (0.52) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL6611923 | 0.82 | NPSR1 (0.49) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL6616180 | 0.82 | MAPT (0.58) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL6610651 | 0.81 | MAPT (0.51) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL6613176 | 0.81 | NPSR1 (0.48) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL6612433 | 0.81 | MAPT (0.53) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL27599294 | 0.80 | MEN1 (0.51) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL6611567 | 0.80 | NPY5R (0.51) | MAPTMEN1KMT2AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | claimed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | claimed |
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |