Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 11/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614376 | 0.92 | MAPT (0.46) | NPSR1MAPTL3MBTL1KDM4EMEN1 | |
| SCHEMBL6611824 | 0.87 | NPY5R (0.52) | NPSR1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL5842037 | 0.86 | MAPT (0.57) | NPSR1MAPTL3MBTL1KDM4EMEN1 | |
| SCHEMBL6612433 | 0.85 | MAPT (0.53) | NPSR1MAPTL3MBTL1KDM4EMEN1 | |
| SCHEMBL6611923 | 0.85 | NPSR1 (0.49) | NPSR1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL6614770 | 0.84 | MAPT (0.48) | NPSR1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL6611567 | 0.82 | NPY5R (0.51) | NPSR1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL6608899 | 0.82 | NPY5R (0.63) | NPSR1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL6609640 | 0.82 | RORC (0.50) | NPSR1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL6610441 | 0.81 | MAPT (0.52) | NPSR1MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |