⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21751884 | 1.00 | — | — | |
| SCHEMBL21751920 | 1.00 | — | — | |
| SCHEMBL3319204 | 0.73 | — | — | |
| SCHEMBL9231614 | 0.73 | — | — | |
| SCHEMBL385475 | 0.70 | — | — | |
| SCHEMBL22405262 | 0.70 | — | — | |
| SCHEMBL21751842 | 0.70 | — | — | |
| SCHEMBL3523924 | 0.70 | — | — | |
| SCHEMBL1263316 | 0.70 | — | — | |
| SCHEMBL662112 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240200070-A1 | EXPANDING THE CHEMICAL SUBSTRATES FOR GENETIC CODE REPROGRAMMING | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2024-06-20 | — | — | US | claimed |
| US-20230295613-A1 | LONG CHAIN CARBON AND CYCLIC AMINO ACIDS SUBSTRATES FOR GENETIC CODE REPROGRAMMING | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2023-09-21 | — | — | US | claimed |
| CN-115867648-A | Extension of chemical substrates for genetic code reprogramming to include long chain carbons and cyclic amino acids | 西北大学 | 2023-03-28 | — | — | CN | claimed |
| EP-4103734-A2 | LONG CHAIN CARBON AND CYCLIC AMINO ACIDS SUBSTRATES FOR GENETIC CODE REPROGRAMMING | Northwestern University (US) | 2022-12-21 | — | — | EP | claimed |
| WO-2021221760-A2 | EXPANDING THE CHEMICAL SUBSTRATES FOR GENETIC CODE REPROGRAMMING TO INCLUDE LONG CHAIN CARBON AND CYCLIC AMINO ACIDS | NORTHWESTERN UNIVERSITY (US) | 2021-11-04 | — | — | WO | claimed |
| US-20210230586-A1 | Expanding the Chemical Substrates for Genetic Code Reprogramming | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, THE | 2021-07-29 | — | — | US | claimed |
| WO-2020040840-A2 | EXPANDING THE CHEMICAL SUBSTRATES FOR GENETIC CODE REPROGRAMMING | NORTHWESTERN UNIVERSITY (US) | 2020-02-27 | — | — | WO | claimed |
| CN-104961666-B | 2-mercaptoacetamide pleuromutilin derivatives, and preparation method and medical application thereof | 南通大学 | 2017-04-12 | — | — | CN | claimed |
| CN-104447450-B | Cysteine amide-type pleuromutilin derivative and preparation method and medical usage | 南通大学 | 2016-09-28 | — | — | CN | claimed |
| US-20160199372-A1 | IMIDAZOPYRIDAZINE KINASE INHIBITORS USEFUL TO TREATING A DISEASE OR DISORDER MEDIATED BY AAK1, SUCH AS ALZHEIMER'S DISEASE, BIPOLAR DISORDER, PAIN, SCHIZOPHRENIA | BRISTOL MYERS SQUIBB CO (US) | 2016-07-14 | — | — | US | claimed |
| CN-104961666-A | 2-mercaptoacetamide pleuromutilin derivatives, and preparation method and medical application thereof | UNIV NANTONG | 2015-10-07 | — | — | CN | claimed |
| CN-104447450-A | Cysteine amide type pleuromutilin derivative as well as preparation method and medical application thereof | UNIV NANTONG | 2015-03-25 | — | — | CN | claimed |
| WO-2015026574-A1 | IMIDAZOPYRIDAZINE KINASE INHIBITORS USEFUL TO TREATING A DISEASE OR DISORDER MEDIATED BY AAK1, SUCH AS ALZHEIMER'S DISEASE, BIPOLAR DISORDER, PAIN, SCHIZOPHRENIA | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-02-26 | — | — | WO | claimed |
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | claimed |
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | claimed |
| CN-102712640-A | Tricyclic heterocyclic compounds, compositions and methods of use thereof | HOFFMANN LA ROCHE | 2012-10-03 | — | — | CN | claimed |
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2011-08-18 | — | — | US | claimed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | claimed |
| CN-101293888-A | Xanthine derivative, production and use thereof as a medicament | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-10-29 | — | — | CN | claimed |
| CN-1492870-A | Xanthine derivatives, process for their preparation and their use as pharmaceutical compositions | ���ָ��Ӣ��ķ�������Ϲ�˾ | 2004-04-28 | — | — | CN | claimed |