Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 11/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 7/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10026247 | 0.74 | ENPP1 (0.60) | ENPP1KDRERBB2HDAC3HDAC4 | |
| SCHEMBL7409382 | 0.74 | CYP2D6 (0.34) | — | |
| SCHEMBL31258474 | 0.73 | ENPP1 (0.43) | ENPP1KDREPHA2EPHB4ERBB2 | |
| SCHEMBL6611547 | 0.71 | EPHA2 (0.50) | ENPP1KDREPHA2EPHB4ERBB2 | |
| SCHEMBL3133518 | 0.71 | EPHA2 (0.50) | ENPP1KDREPHA2EPHB4ERBB2 | |
| SCHEMBL3132212 | 0.71 | EPHA2 (0.50) | ENPP1KDREPHA2EPHB4ERBB2 | |
| SCHEMBL664787 | 0.70 | EPHA2 (0.52) | ENPP1KDREPHA2EPHB4ERBB2 | |
| SCHEMBL17179600 | 0.70 | EPHA2 (0.52) | ENPP1KDREPHA2EPHB4ERBB2 | |
| SCHEMBL16760460 | 0.70 | ENPP1 (0.67) | ENPP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL5214519 | 0.70 | ENPP1 (0.52) | ENPP1KDREPHA2EPHB4ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487806-A1 | 4-ANILINO QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | Astrazeneca AB (SE) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003082831-A1 | 4-ANILINO QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |