Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.78 |
| ▸ | HTR1D | P28221 | 20/20 | 0.78 |
| ▸ | HTR1B | P28222 | 20/20 | 0.78 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | HTR1E | P28566 | 1/20 | 0.68 |
| ▸ | HTR1F | P30939 | 1/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.68 |
| ▸ | HTR7 | P34969 | 1/20 | 0.68 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.68 |
| ▸ | HTR2B | P41595 | 1/20 | 0.68 |
| ▸ | HTR5A | P47898 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6398599 | 0.92 | HTR1A (0.76) | HTR1AHTR1DHTR1BADRB2DRD2 | |
| SCHEMBL6392131 | 0.91 | HTR1A (0.80) | HTR1AHTR1DHTR1BADRB2DRD2 | |
| SCHEMBL6394575 | 0.91 | HTR1A (0.76) | HTR1AHTR1DHTR1BADRB2DRD2 | |
| SCHEMBL6392500 | 0.91 | HTR1A (0.73) | HTR1AHTR1DHTR1BADRB2DRD2 | |
| SCHEMBL6393797 | 0.90 | HTR1A (0.75) | HTR1AHTR1DHTR1BADRB2DRD2 | |
| SCHEMBL6391232 | 0.89 | HTR1A (0.74) | HTR1AHTR1DHTR1BADRB2DRD2 | |
| SCHEMBL6391980 | 0.89 | HTR1A (0.75) | HTR1AHTR1DHTR1BADRB2DRD2 | |
| SCHEMBL6392425 | 0.88 | HTR1A (0.72) | HTR1AHTR1DHTR1BADRB2DRD2 | |
| SCHEMBL6391984 | 0.88 | HTR1A (0.75) | HTR1AHTR1DHTR1BADRB2DRD2 | |
| SCHEMBL5214315 | 0.88 | HTR1A (1.00) | HTR1AHTR1DHTR1BADRB2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476161-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES POSSESSING AFFINITY AT 5HT-1 TYPE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068236-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES POSSESSING AFFINITY AT 5HT-1 TYPE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |