Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6612475 | 1.00 | FLT3 (0.41) | FLT3PDGFRBKDRPAK1PIM1 | |
| SCHEMBL4990931 | 0.92 | FLT3 (0.47) | FLT3PDGFRBKDRPAK1PIM1 | |
| SCHEMBL4990928 | 0.92 | FLT3 (0.47) | FLT3PDGFRBKDRPAK1PIM1 | |
| SCHEMBL4994170 | 0.92 | ALDH1A1 (0.42) | FLT3PAK1SCN5AAURKAAURKB | |
| SCHEMBL4994178 | 0.92 | ALDH1A1 (0.42) | FLT3PAK1SCN5AAURKAAURKB | |
| SCHEMBL4990835 | 0.85 | PAK1 (0.39) | FLT3PAK1ALDH1A1CRHBPHTT | |
| SCHEMBL4990826 | 0.85 | PAK1 (0.39) | FLT3PAK1ALDH1A1CRHBPHTT | |
| SCHEMBL4992447 | 0.85 | FLT3 (0.49) | FLT3PDGFRBKDRPAK1PIM1 | |
| SCHEMBL4992442 | 0.85 | FLT3 (0.49) | FLT3PDGFRBKDRPAK1PIM1 | |
| SCHEMBL4997102 | 0.85 | SCN5A (0.45) | FLT3PDGFRBKDRPAK1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |