Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 | Q14654 | 14/20 | 0.59 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.44 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7691318 | 0.90 | KCNJ11 (0.57) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL6613378 | 0.89 | KCNQ3 (0.57) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL6646019 | 0.85 | MEN1 (0.48) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL6611716 | 0.82 | MEN1 (0.45) | KCNJ11CYP2D6ABCC9ABCC8KCNJ8 | |
| SCHEMBL4677817 | 0.81 | KCNJ11 (0.70) | KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL4677822 | 0.81 | KCNJ11 (0.70) | KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL6615854 | 0.81 | KCNJ11 (0.54) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL6611765 | 0.81 | KCNJ11 (0.58) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL6642968 | 0.78 | MEN1 (0.44) | KCNJ11CYP2D6 | |
| SCHEMBL6613703 | 0.78 | KCNQ3 (0.54) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |