Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613378 | 0.89 | KCNQ3 (0.57) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL7691318 | 0.87 | KCNJ11 (0.57) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL6612971 | 0.85 | KCNJ11 (0.59) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL4678436 | 0.82 | KCNJ11 (0.56) | MEN1KMT2AKEAP1NFE2L2KCNJ11 | |
| SCHEMBL4678433 | 0.82 | KCNJ11 (0.56) | MEN1KMT2AKEAP1NFE2L2KCNJ11 | |
| SCHEMBL6611765 | 0.82 | KCNJ11 (0.58) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL6615879 | 0.81 | P2RX7 (0.48) | MEN1KMT2AKCNJ11RAB9AABCC9 | |
| SCHEMBL6615854 | 0.80 | KCNJ11 (0.54) | KCNJ11KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL6611716 | 0.79 | MEN1 (0.45) | MEN1KMT2AKCNJ11RAB9ASMN1; SMN2 | |
| SCHEMBL810725 | 0.78 | KCNJ11 (0.54) | MEN1KMT2AKEAP1NFE2L2KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |