Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.97 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039655 | 0.98 | EGFR (1.00) | EGFRSRCERBB2 | |
| SCHEMBL4040983 | 0.89 | EGFR (0.82) | EGFRSRCERBB2 | |
| SCHEMBL5662811 | 0.88 | EGFR (0.81) | EGFRSRCERBB2 | |
| SCHEMBL2494257 | 0.88 | EGFR (0.81) | EGFRSRCERBB2 | |
| SCHEMBL4034609 | 0.88 | EGFR (1.00) | EGFRSRCERBB2 | |
| SCHEMBL4036906 | 0.87 | EGFR (0.85) | EGFRSRCERBB2 | |
| SCHEMBL5662719 | 0.87 | EGFR (0.79) | EGFRSRCERBB2 | |
| SCHEMBL4034575 | 0.86 | EGFR (0.78) | EGFRSRCERBB2 | |
| SCHEMBL4034383 | 0.86 | EGFR (1.00) | EGFRSRCERBB2 | |
| SCHEMBL4034115 | 0.85 | EGFR (0.83) | EGFRSRCERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-A2 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040109-A2 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |