Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6612753 | 0.88 | ALDH1A1 (0.46) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6616317 | 0.86 | ALDH1A1 (0.45) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6615489 | 0.86 | KMT2A (0.47) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6610452 | 0.85 | NPC1 (0.38) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6612284 | 0.82 | CYP1A2 (0.48) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6613895 | 0.80 | ALDH1A1 (0.45) | ALDH1A1HTTSMN1; SMN2KMT2AHPGD | |
| SCHEMBL6610072 | 0.80 | HPGD (0.48) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6615636 | 0.79 | NPC1 (0.40) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6610804 | 0.78 | PDE4A (0.39) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6475759 | 0.78 | KMT2A (0.48) | ALDH1A1SMN1; SMN2KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252157-B1 | PYRIMIDINE CARBOXAMIDES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PROD INC (US) | 2004-06-23 | — | — | EP | claimed |