Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 7/20 | 0.39 |
| ▸ | CA9 | Q16790 | 7/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | FGB | P02675 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459411 | 0.85 | GAA (0.38) | MAPTKDM4ECA12CA9GAA | |
| SCHEMBL3459409 | 0.85 | GAA (0.38) | MAPTKDM4ECA12CA9GAA | |
| SCHEMBL3458674 | 0.81 | NR4A2 (0.36) | MAPTKDM4ECA12CA9GAA | |
| SCHEMBL3458675 | 0.81 | NR4A2 (0.36) | MAPTKDM4ECA12CA9GAA | |
| SCHEMBL6341328 | 0.77 | NR4A2 (0.38) | CA12CA9CA2F2 | |
| SCHEMBL8130282 | 0.77 | KDM4E (0.42) | MAPTKDM4EKMT2AMEN1HPGD | |
| SCHEMBL6618718 | 0.75 | RARB (0.41) | MAPTKMT2AMEN1HPGDMAPK1 | |
| SCHEMBL24376254 | 0.73 | PPARG (0.43) | MAPTKDM4ECRBNHTTHSD17B10 | |
| SCHEMBL17158191 | 0.72 | CA12 (0.47) | KDM4ECA12CA9 | |
| SCHEMBL20699419 | 0.71 | PPARG (0.43) | MAPTHSD17B10PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423376-A1 | BICYCLIC COMPOUND, PRODUCTION AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003014105-A1 | BICYCLIC COMPOUND, PRODUCTION AND USE AS HIV INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-02-20 | — | — | WO | disclosed |