Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.43 |
| ▸ | RAB9A | P51151 | 13/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621559 | 0.89 | RAB9A (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6615958 | 0.87 | KDM4C (0.49) | RAB9AMEN1KMT2AMAPK14 | |
| SCHEMBL6619084 | 0.87 | RAB9A (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6618868 | 0.85 | RAB9A (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6615838 | 0.85 | MAPT (0.46) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6618662 | 0.85 | KMT2A (0.38) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6604492 | 0.85 | CRACR2A (0.39) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL6619885 | 0.84 | RAB9A (0.43) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6603518 | 0.83 | MAPT (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6618222 | 0.83 | RAB9A (0.43) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |