Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4876589 | 1.00 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3KCNH2KDM4E | |
| SCHEMBL4869830 | 1.00 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3KCNH2KDM4E | |
| SCHEMBL4874534 | 0.90 | QDPR (0.39) | SLC6A2SLC6A4SLC6A3KCNH2HTR6 | |
| SCHEMBL1824248 | 0.84 | MEN1 (0.46) | SLC6A2SLC6A4SLC6A3KCNH2KDM4E | |
| SCHEMBL1824302 | 0.81 | OPRL1 (0.46) | SLC6A2SLC6A4SLC6A3KCNH2HTR6 | |
| SCHEMBL8088234 | 0.77 | KDM4E (0.53) | KDM4EATMHTR6HTR1AHTR1D | |
| SCHEMBL1822196 | 0.74 | KDM4E (0.47) | SLC6A2SLC6A4SLC6A3KCNH2KDM4E | |
| SCHEMBL4969638 | 0.73 | OPRL1 (0.47) | HTR1AHTR1D | |
| SCHEMBL2215498 | 0.73 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3KCNH2KDM4E | |
| SCHEMBL14924437 | 0.72 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467986-A1 | AZA-CYCLIC COMPOUNDS AS MODULATORS OF ACETYLCHOLINE RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003062224-A1 | AZA-CYCLIC COMPOUNDS AS MODULATORS OF ACETYLCHOLINE RECEPTORS | ELI LILLY AND COMPANY (US) | 2003-07-31 | — | — | WO | disclosed |