Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 7/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 5/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617382 | 0.94 | RAF1 (0.42) | POLBCTDSP1RAF1PTGS1LMNA | |
| SCHEMBL6651874 | 0.88 | POLB (0.47) | POLBCTDSP1RAF1PTGS1BRAF | |
| SCHEMBL6614038 | 0.88 | KCNK3 (0.44) | POLBCTDSP1RAF1PTGS1LMNA | |
| SCHEMBL6626821 | 0.86 | RAF1 (0.46) | POLBCTDSP1RAF1PTGS1LMNA | |
| SCHEMBL6618177 | 0.86 | POLB (0.47) | POLBCTDSP1RAF1PTGS1LMNA | |
| SCHEMBL6615991 | 0.86 | NPSR1 (0.46) | POLBCTDSP1RAF1PTGS1BRAF | |
| SCHEMBL6603511 | 0.86 | MEN1 (0.39) | LMNAMAPK14MAPT | |
| SCHEMBL6616122 | 0.84 | RAF1 (0.46) | POLBCTDSP1RAF1BRAFADCY8 | |
| SCHEMBL6620165 | 0.83 | RAF1 (0.44) | POLBCTDSP1RAF1LMNABRAF | |
| SCHEMBL6618212 | 0.83 | CCR2 (0.43) | POLBCTDSP1RAF1PTGS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |