Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6093964 | 0.95 | GPR119 (0.43) | GPR119EGLN2JAK2JAK1HRH2 | |
| SCHEMBL6621239 | 0.87 | EPHX2 (0.43) | GPR119EGLN2JAK2JAK1HRH2 | |
| SCHEMBL6094707 | 0.87 | HRH2 (0.38) | GPR119EGLN2HRH2HRH1DRD2 | |
| SCHEMBL6608888 | 0.87 | CCR3 (0.36) | HRH2HRH1DRD2AR | |
| SCHEMBL2961116 | 0.86 | KCNH2 (0.44) | GPR119EGLN2JAK2JAK1 | |
| SCHEMBL6093467 | 0.86 | HRH2 (0.37) | GPR119EGLN2JAK2JAK1HRH2 | |
| SCHEMBL6321858 | 0.86 | CCR3 (0.41) | HRH2HRH1DRD2 | |
| SCHEMBL6094571 | 0.83 | HRH1 (0.49) | HRH2HRH1DRD2 | |
| SCHEMBL5965506 | 0.82 | GPR119 (0.43) | GPR119HRH2HRH1DRD2AR | |
| SCHEMBL5966001 | 0.82 | GPR119 (0.45) | GPR119EGLN2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | claimed |
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |