Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 6/20 | 0.58 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.44 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436998 | 0.95 | HCRTR1 (0.54) | HCRTR1HCRTR2CHEK2KMT2AHRH2 | |
| SCHEMBL4321825 | 0.89 | CHEK2 (0.56) | HCRTR1HCRTR2CHEK2HRH2HRH1 | |
| SCHEMBL6609250 | 0.89 | CHEK2 (0.56) | HCRTR1HCRTR2CHEK2HRH2HRH1 | |
| SCHEMBL7399721 | 0.88 | CHEK2 (0.61) | HCRTR1HCRTR2CHEK2KMT2AHRH2 | |
| SCHEMBL8346932 | 0.87 | CHEK2 (0.56) | HCRTR1HCRTR2CHEK2HRH2HRH1 | |
| SCHEMBL8346931 | 0.87 | CHEK2 (0.56) | HCRTR1HCRTR2CHEK2HRH2HRH1 | |
| SCHEMBL4328668 | 0.85 | ALOX5AP (0.50) | KMT2AGPR119ALOX5APFEN1ABHD6 | |
| SCHEMBL4328662 | 0.85 | ALOX5AP (0.50) | KMT2AGPR119ALOX5APFEN1ABHD6 | |
| SCHEMBL4312971 | 0.85 | CHEK2 (0.54) | HCRTR1HCRTR2CHEK2KMT2A | |
| SCHEMBL7359533 | 0.85 | PRMT5 (0.58) | HCRTR1HCRTR2CHEK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435955-A2 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SmithKline Beecham P.L.C. (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2002089800-A2 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-11-14 | — | — | WO | disclosed |