Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046246 | 0.92 | CHEK2 (0.54) | PRMT5CHEK2KDM4ENPC1RAB9A | |
| SCHEMBL4312971 | 0.92 | CHEK2 (0.54) | PRMT5CHEK2KDM4ENPC1RAB9A | |
| SCHEMBL6609250 | 0.92 | CHEK2 (0.56) | PRMT5CHEK2KDM4ENPC1RAB9A | |
| SCHEMBL4314170 | 0.89 | PRMT5 (0.56) | PRMT5KDM4EALDH1A1KLK7CHRNB2 | |
| SCHEMBL4314700 | 0.89 | PRMT5 (0.56) | PRMT5KDM4EALDH1A1KLK7CHRNB2 | |
| SCHEMBL2895175 | 0.89 | PRMT5 (0.56) | PRMT5KDM4EALDH1A1KLK7CHRNB2 | |
| SCHEMBL30428901 | 0.88 | PRMT5 (0.50) | PRMT5CHEK2HTTHCRTR1HCRTR2 | |
| SCHEMBL7324862 | 0.88 | CHEK2 (0.58) | PRMT5CHEK2KDM4ENPC1RAB9A | |
| SCHEMBL6610956 | 0.87 | KLK7 (0.50) | PRMT5CHEK2NPC1RAB9AL3MBTL1 | |
| SCHEMBL7399721 | 0.86 | CHEK2 (0.61) | CHEK2NPC1RAB9AHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674514-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013291-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1994-06-23 | — | — | WO | disclosed |