Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636013 | 0.94 | PNMT (0.62) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL31378863 | 0.77 | PNMT (0.58) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL427407 | 0.77 | PNMT (0.58) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL24982 | 0.74 | MAPT (0.49) | PNMTADRA2AMAPTNPC1RAB9A | |
| SCHEMBL395008 | 0.74 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL29581896 | 0.74 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL27632113 | 0.74 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CMAPT | |
| Acetaldehyde SCHEMBL27778138 | 0.74 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CMAPT | |
| Hydrochloric Acid SCHEMBL1997634 | 0.73 | MAPT (0.47) | PNMTADRA2AMAPTNPC1RAB9A | |
| SCHEMBL397538 | 0.73 | PNMT (0.50) | PNMTADRA2AADRA2BADRA2CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892797-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-0892797-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030992-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |