Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17158249 | 0.78 | KDM1A (0.49) | NPC1RAB9ASMN1; SMN2STSALDH1A1 | |
| SCHEMBL12404088 | 0.75 | BRD4 (0.46) | SMN1; SMN2STSALDH1A1PTPN2PTPN1 | |
| SCHEMBL2770672 | 0.74 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2STSALDH1A1 | |
| SCHEMBL6290081 | 0.73 | MAPT (0.39) | NPC1GPR119MAPTKDM4EPKM | |
| SCHEMBL5434164 | 0.73 | MAPT (0.39) | NPC1GPR119MAPTKDM4EPKM | |
| SCHEMBL26984184 | 0.70 | NR1H2 (0.47) | NPC1RAB9ASMN1; SMN2STSALDH1A1 | |
| SCHEMBL27128033 | 0.70 | NR1H2 (0.47) | NPC1RAB9ASMN1; SMN2STSALDH1A1 | |
| SCHEMBL21494384 | 0.69 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL28730461 | 0.69 | HSD17B10 (0.41) | SMN1; SMN2STSGPR119GAAPTPN2 | |
| SCHEMBL6617875 | 0.68 | NR1H2 (0.46) | NPC1RAB9ASMN1; SMN2STSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395574-A1 | 4-(PHENYL-PIPERIDIN-4-YLIDENE-METHYL)-BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS | AstraZeneca AB (SE) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002094810-A1 | 4-(PHENYL-PIPERIDIN-4-YLIDENE-METHYL)-BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2002-11-28 | — | — | WO | disclosed |