Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621376 | 0.98 | KMT2A (0.39) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6616453 | 0.94 | KMT2A (0.36) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6618534 | 0.91 | NPY2R (0.38) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6617100 | 0.90 | NPC1 (0.40) | KMT2AMEN1ALDH1A1POLBRAB9A | |
| SCHEMBL6603251 | 0.89 | HRH3 (0.41) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6622256 | 0.89 | ADORA3 (0.39) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6617170 | 0.88 | KMT2A (0.45) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6614960 | 0.87 | HRH3 (0.39) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6620279 | 0.87 | KMT2A (0.38) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6617610 | 0.87 | KMT2A (0.40) | KMT2AMEN1CYP1A2CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |