Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621038 | 0.90 | AVPR2 (0.43) | AVPR2SHMT2LMNATP53MAPT | |
| SCHEMBL6617113 | 0.90 | AVPR2 (0.46) | AVPR2SHMT2TP53MAPT | |
| SCHEMBL6615887 | 0.89 | AVPR2 (0.49) | AVPR2SHMT2LMNATP53MAPT | |
| SCHEMBL6620011 | 0.83 | AVPR2 (0.69) | AVPR2LMNA | |
| SCHEMBL7344491 | 0.79 | TP53 (0.40) | SHMT2TP53MAPT | |
| SCHEMBL7325709 | 0.77 | AVPR2 (0.70) | AVPR2 | |
| SCHEMBL7335243 | 0.76 | AVPR2 (0.48) | AVPR2 | |
| SCHEMBL7334278 | 0.76 | AVPR2 (0.43) | AVPR2 | |
| SCHEMBL7017866 | 0.75 | TP53 (0.46) | SHMT2LMNATP53MAPT | |
| SCHEMBL7024798 | 0.74 | TP53 (0.47) | SHMT2LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000059-B1 | TRICYCLIC VASOPRESSIN AGONISTS | WYETH CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6194407-B1 | INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION | 2001-02-27 | — | — | US | disclosed |
| US-6090803-A | ANTIDIABETIC AGENTS; INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-18 | — | — | US | disclosed |
| EP-1000059-A1 | TRICYCLIC VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999006403-A1 | TRICYCLIC VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |