Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621978 | 0.88 | PDGFRB (0.45) | PDGFRBPDGFRAGRIN2BFGFR1FGFR2 | |
| SCHEMBL6619419 | 0.87 | PDGFRB (0.47) | PDGFRBPDGFRAGRIN2BFGFR1FGFR2 | |
| SCHEMBL6620040 | 0.86 | PDGFRB (0.50) | PDGFRBPDGFRAGRIN2BFGFR1FGFR2 | |
| SCHEMBL6618297 | 0.85 | PDGFRB (0.44) | PDGFRBPDGFRAGRIN2BFGFR1FGFR2 | |
| Dimethylamine SCHEMBL6616891 | 0.84 | PDGFRB (0.45) | PDGFRBPDGFRAGRIN2BFLT3BRD4 | |
| SCHEMBL6630468 | 0.84 | MCHR1 (0.42) | PDGFRBPDGFRAGRIN2BFGFR1FGFR2 | |
| SCHEMBL6621864 | 0.83 | PDGFRB (0.44) | PDGFRBPDGFRAGRIN2BFGFR1FGFR2 | |
| SCHEMBL6618914 | 0.83 | GRIN2B (0.43) | PDGFRBPDGFRAGRIN2BFGFR1FGFR2 | |
| SCHEMBL6621834 | 0.83 | GRIN2B (0.43) | PDGFRBPDGFRAGRIN2BFGFR1FGFR2 | |
| SCHEMBL6616763 | 0.83 | GRIN2B (0.47) | PDGFRBPDGFRAGRIN2BFLT3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |