Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621978 | 0.86 | PDGFRB (0.45) | PDGFRBPDGFRAFGFR3FGFR1FGFR2 | |
| SCHEMBL6619419 | 0.85 | PDGFRB (0.47) | PDGFRBPDGFRAFGFR3FGFR1FGFR2 | |
| SCHEMBL6616151 | 0.84 | PDGFRB (0.43) | PDGFRBPDGFRAFGFR3FGFR1FGFR2 | |
| SCHEMBL6620040 | 0.83 | PDGFRB (0.50) | PDGFRBPDGFRAFGFR3FGFR1FGFR2 | |
| Dimethylamine SCHEMBL6616891 | 0.82 | PDGFRB (0.45) | PDGFRBPDGFRAFLT3BRD4GRIN2B | |
| SCHEMBL6658013 | 0.82 | PDGFRB (0.41) | PDGFRBPDGFRAFGFR3FGFR1FGFR2 | |
| SCHEMBL6621864 | 0.81 | PDGFRB (0.44) | PDGFRBPDGFRAFGFR3FGFR1FGFR2 | |
| SCHEMBL6618297 | 0.81 | PDGFRB (0.44) | PDGFRBPDGFRAFGFR3FGFR1FGFR2 | |
| SCHEMBL6618914 | 0.81 | GRIN2B (0.43) | PDGFRBPDGFRAFGFR3FGFR1FGFR2 | |
| SCHEMBL6621834 | 0.81 | GRIN2B (0.43) | PDGFRBPDGFRAFGFR3FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |