Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613271 | 0.94 | SMN1; SMN2 (0.41) | NPC1MAPTRAB9AGAAACKR3 | |
| SCHEMBL6617571 | 0.93 | NPC1 (0.43) | NPC1MAPTRAB9AGAAACKR3 | |
| SCHEMBL6615130 | 0.91 | ABCG2 (0.42) | NPC1MAPTRAB9AGAAACKR3 | |
| SCHEMBL6615007 | 0.91 | NPC1 (0.39) | NPC1MAPTRAB9AGAAACKR3 | |
| SCHEMBL6607824 | 0.89 | MAPT (0.42) | NPC1MAPTRAB9AGAAACKR3 | |
| SCHEMBL6602903 | 0.88 | NPC1 (0.40) | NPC1MAPTRAB9AGAAACKR3 | |
| SCHEMBL6616477 | 0.87 | NPC1 (0.45) | NPC1MAPTRAB9AGAAACKR3 | |
| SCHEMBL6650207 | 0.87 | NPC1 (0.47) | NPC1MAPTRAB9AGAAACKR3 | |
| SCHEMBL6613706 | 0.84 | HDAC2 (0.43) | GAAKDM4E | |
| SCHEMBL6619848 | 0.84 | PPARG (0.42) | MAPTRAB9AACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |