Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616349 | 0.94 | NPC1 (0.39) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL6617571 | 0.94 | NPC1 (0.43) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL6607824 | 0.93 | MAPT (0.42) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL6650207 | 0.93 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL6615130 | 0.92 | ABCG2 (0.42) | NPC1RAB9AMAPTGAAACKR3 | |
| SCHEMBL6615007 | 0.92 | NPC1 (0.39) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL6602903 | 0.90 | NPC1 (0.40) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL6616477 | 0.90 | NPC1 (0.45) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL6619520 | 0.86 | RAB9A (0.43) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL6614975 | 0.83 | SENP1 (0.45) | GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |