Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.44 |
| ▸ | PRKCA | P17252 | 4/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 6/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6618250 | 0.99 | GSK3B (0.53) | GSK3BCCNE2CCNE1CDK2IKBKE | |
| SCHEMBL6614071 | 0.85 | GSK3B (0.58) | GSK3BCCNE2CCNE1CDK2IKBKE | |
| Hydrochloric Acid SCHEMBL6656953 | 0.85 | GSK3B (0.57) | GSK3BCCNE2CCNE1CDK2IKBKE | |
| SCHEMBL6034173 | 0.81 | GSK3B (0.53) | GSK3BCCNE2CCNE1CDK2IKBKE | |
| Hydrochloric Acid SCHEMBL6034194 | 0.80 | GSK3B (0.56) | GSK3BCCNE2CCNE1CDK2IKBKE | |
| Hydrochloric Acid SCHEMBL6034701 | 0.79 | GSK3B (0.78) | GSK3BCCNE2CCNE1CDK2PIM2 | |
| Hydrochloric Acid SCHEMBL6035062 | 0.79 | GSK3B (0.78) | GSK3BCCNE2CCNE1CDK2PIM2 | |
| SCHEMBL23420480 | 0.78 | GSK3B (0.57) | GSK3BPIM2PRKCAPRKCQPIM1 | |
| Hydrochloric Acid SCHEMBL6034877 | 0.75 | GSK3B (0.76) | GSK3BCCNE2CCNE1CDK2PIM2 | |
| SCHEMBL6618758 | 0.74 | ATR (0.63) | GSK3BCCNE2CCNE1CDK2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040186113-A1 | Heterocyclic amines for the treatment of conditions associated with gsk-3 | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | US | claimed |
| EP-1406877-A1 | HETEROCYCLIC AMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-04-14 | — | — | EP | claimed |
| WO-2003004475-A1 | HETEROCYCLIC AMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | claimed |
| US-20040186113-A1 | Heterocyclic amines for the treatment of conditions associated with gsk-3 | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | US | disclosed |
| EP-1406877-A1 | HETEROCYCLIC AMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003004475-A1 | HETEROCYCLIC AMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186113-A1 | Heterocyclic amines for the treatment of conditions associated with gsk-3 | GSK3A, GSK3B, PYGL | GSK3B 2/4885CCNE2 630/4885CCNE1 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.