Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | MC5R | P33032 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
| ▸ | MC1R | Q01726 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614701 | 0.79 | SLC6A4 (0.44) | HTR1ASLC6A4 | |
| SCHEMBL6801384 | 0.72 | SLC6A4 (0.56) | CDK2HTR1ASLC6A4MEN1LMNA | |
| SCHEMBL6801386 | 0.72 | SLC6A4 (0.56) | CDK2HTR1ASLC6A4MEN1LMNA | |
| SCHEMBL5292952 | 0.70 | MC5R (0.66) | CDK2HTR1AMEN1LMNAMAPT | |
| SCHEMBL8264766 | 0.69 | CDK2 (0.61) | CDK2HTR1AALOX5APMEN1LMNA | |
| SCHEMBL6616745 | 0.69 | CDK2 (0.49) | CDK2ALOX5APSLC6A4MEN1LMNA | |
| SCHEMBL9827979 | 0.68 | HTR2A (0.64) | CDK2SLC6A4KMT2AMC5RMC3R | |
| SCHEMBL17232881 | 0.67 | MC5R (0.83) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL10491369 | 0.66 | HTR2A (0.70) | HTR1AMEN1LMNAKMT2ABCHE | |
| SCHEMBL6636440 | 0.66 | SMO (0.54) | HTR1ASLC6A4MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373203-A1 | CYCLOPROPYLINDOLE DERIVATIVES AS SELECTIVE SEROTONIN REUPTAKE INHIBITORS | Bristol-Myers Squibb Company (US) | 2004-01-02 | — | — | EP | claimed |
| WO-2002079152-A1 | CYCLOPROPYLINDOLE DERIVATIVES AS SELECTIVE SEROTONIN REUPTAKE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-10-10 | — | — | WO | claimed |