Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614668 | 0.91 | MGLL (0.55) | SMN1; SMN2HPGDPOLBBCHEMAOB | |
| SCHEMBL6611690 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDPOLBBCHEMAOB | |
| SCHEMBL6610739 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2HPGDPOLBATMKMT2A | |
| SCHEMBL6611026 | 0.81 | HPGD (0.53) | SMN1; SMN2HPGDPOLBATMKMT2A | |
| SCHEMBL5842481 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2HPGDPOLBKMT2ATP53 | |
| SCHEMBL6612851 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDPOLBBCHEATM | |
| SCHEMBL6611567 | 0.79 | NPY5R (0.51) | SMN1; SMN2HPGDKMT2ATP53MEN1 | |
| SCHEMBL27412760 | 0.79 | POLB (0.53) | SMN1; SMN2HPGDPOLBATMKMT2A | |
| SCHEMBL6613618 | 0.79 | GFER (0.44) | SMN1; SMN2HPGDPOLBBCHEATM | |
| SCHEMBL6613455 | 0.78 | NPC1 (0.45) | SMN1; SMN2BCHEMAOBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |