Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 4/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618733 | 1.00 | FGFR2 (0.65) | FGFR2FGFR1FGFR3NPC1RAB9A | |
| SCHEMBL8116664 | 1.00 | FGFR2 (0.65) | FGFR2FGFR1FGFR3NPC1RAB9A | |
| SCHEMBL9133005 | 0.91 | FGFR2 (0.57) | FGFR2FGFR1FGFR3NPC1RAB9A | |
| SCHEMBL6616674 | 0.88 | FGFR1 (0.48) | FGFR2FGFR1FGFR3NPC1RAB9A | |
| SCHEMBL6620076 | 0.88 | FGFR1 (0.48) | FGFR2FGFR1FGFR3NPC1RAB9A | |
| SCHEMBL6619870 | 0.82 | BCHE (0.54) | FGFR2FGFR1FGFR3NPC1RAB9A | |
| SCHEMBL6617130 | 0.82 | BCHE (0.54) | FGFR2FGFR1FGFR3NPC1RAB9A | |
| SCHEMBL6616738 | 0.80 | SMN1; SMN2 (0.58) | FGFR1NPC1RAB9AMAPTGAA | |
| SCHEMBL6615661 | 0.80 | FGFR2 (0.56) | FGFR2FGFR1FGFR3NPC1MAPT | |
| SCHEMBL6618636 | 0.80 | FGFR2 (0.56) | FGFR2FGFR1FGFR3NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |