Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 5/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615661 | 1.00 | FGFR2 (0.56) | FGFR2FGFR1MAPK1TRPA1FGFR3 | |
| SCHEMBL9052838 | 0.91 | FGFR2 (0.48) | FGFR2FGFR1MAPK1TRPA1FGFR3 | |
| SCHEMBL6618595 | 0.89 | PDGFRB (0.51) | FGFR2FGFR1MAPK1PDGFRBPDGFRA | |
| SCHEMBL6616842 | 0.89 | PDGFRB (0.51) | FGFR2FGFR1MAPK1PDGFRBPDGFRA | |
| SCHEMBL9133723 | 0.89 | PDGFRB (0.51) | FGFR2FGFR1MAPK1PDGFRBPDGFRA | |
| SCHEMBL8102827 | 0.80 | FGFR2 (0.39) | FGFR2FGFR1MAPTKDM4EALDH1A1 | |
| SCHEMBL6618763 | 0.80 | MAP3K11 (0.55) | MAPK1PDGFRBPDGFRAMAPTKDM4E | |
| SCHEMBL6618374 | 0.80 | MAP3K11 (0.55) | MAPK1PDGFRBPDGFRAMAPTKDM4E | |
| SCHEMBL6617504 | 0.80 | FGFR2 (0.65) | FGFR2FGFR1MAPK1TRPA1FGFR3 | |
| SCHEMBL8116664 | 0.80 | FGFR2 (0.65) | FGFR2FGFR1MAPK1TRPA1FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |