Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618338 | 1.00 | MAPK1 (0.51) | MAPK1ALDH1A1MAPTGLAGAA | |
| SCHEMBL8112499 | 1.00 | MAPK1 (0.51) | MAPK1ALDH1A1MAPTGLAGAA | |
| SCHEMBL6622035 | 0.88 | GAA (0.44) | MAPK1ALDH1A1MAPTGLAGAA | |
| SCHEMBL6618516 | 0.88 | GAA (0.44) | MAPK1ALDH1A1MAPTGLAGAA | |
| SCHEMBL6616674 | 0.86 | FGFR1 (0.48) | MAPK1ALDH1A1MAPTGLAGAA | |
| SCHEMBL6620076 | 0.86 | FGFR1 (0.48) | MAPK1ALDH1A1MAPTGLAGAA | |
| SCHEMBL6618612 | 0.85 | MAPK1 (0.49) | MAPK1ALDH1A1MAPTGLAGAA | |
| SCHEMBL6621230 | 0.85 | MAPK1 (0.49) | MAPK1ALDH1A1MAPTGLAGAA | |
| SCHEMBL6618374 | 0.85 | MAP3K11 (0.55) | MAPK1ALDH1A1MAPTGLAGAA | |
| SCHEMBL6618763 | 0.85 | MAP3K11 (0.55) | MAPK1ALDH1A1MAPTGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |