Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.40 |
| ▸ | KDR | P35968 | 7/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618516 | 1.00 | GAA (0.44) | GAAMAPTALDH1A1GLASMN1; SMN2 | |
| SCHEMBL8143522 | 0.89 | GAA (0.45) | GAAMAPTALDH1A1GLASMN1; SMN2 | |
| SCHEMBL8112499 | 0.88 | MAPK1 (0.51) | GAAMAPTALDH1A1GLASMN1; SMN2 | |
| SCHEMBL6618338 | 0.88 | MAPK1 (0.51) | GAAMAPTALDH1A1GLASMN1; SMN2 | |
| SCHEMBL6617606 | 0.88 | MAPK1 (0.51) | GAAMAPTALDH1A1GLASMN1; SMN2 | |
| SCHEMBL6616674 | 0.87 | FGFR1 (0.48) | GAAMAPTALDH1A1GLASMN1; SMN2 | |
| SCHEMBL6620076 | 0.87 | FGFR1 (0.48) | GAAMAPTALDH1A1GLASMN1; SMN2 | |
| SCHEMBL6618374 | 0.81 | MAP3K11 (0.55) | GAAMAPTALDH1A1GLASMN1; SMN2 | |
| SCHEMBL6618763 | 0.81 | MAP3K11 (0.55) | GAAMAPTALDH1A1GLASMN1; SMN2 | |
| SCHEMBL6616714 | 0.79 | MAPK1 (0.44) | SMN1; SMN2MAPK1NPC1RAB9AFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |