Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | STAT3 | P40763 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618073 | 0.76 | EGFR (0.43) | KDM4DKDM4CNAMPTKMT2AMEN1 | |
| SCHEMBL6617228 | 0.76 | CA12 (0.36) | NAMPTSMN1; SMN2LMNA | |
| SCHEMBL7083730 | 0.74 | KDM6B (0.44) | KDM4CNAMPTRAB9AKMT2ANPC1 | |
| SCHEMBL8722364 | 0.73 | KDM4D (0.46) | KDM4DKDM4CNAMPTJAK2TYK2 | |
| SCHEMBL6619220 | 0.70 | CA12 (0.34) | SMN1; SMN2LMNA | |
| SCHEMBL6618015 | 0.70 | CA12 (0.34) | KDM4CNAMPTSMN1; SMN2LMNA | |
| SCHEMBL2364650 | 0.69 | CA12 (0.42) | NAMPTSMN1; SMN2KDM4EHCAR3 | |
| SCHEMBL6620058 | 0.69 | CXCR2 (0.31) | — | |
| Water SCHEMBL8623502 | 0.69 | KDM4C (0.38) | KDM4CNAMPTSMN1; SMN2LMNAHCAR3 | |
| SCHEMBL8621101 | 0.69 | LATS1 (0.39) | NAMPTKMT2AMEN1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877748-B1 | PYRIDO-1,2,4-THIADIAZINE AND PYRIDO-1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | UNIV LIEGE (BE) | 2004-11-03 | — | — | EP | disclosed |
| US-5792764-A | ENDOCRINE DISORDERS ESPECIALLY AS A K(ATP)-CHANNEL MODULATOR | NOVO NORDISK A/S (DK) | 1998-08-11 | — | — | US | disclosed |