Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 14/20 | 0.73 |
| ▸ | CX3CR1 | P49238 | 8/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL842178 | 0.84 | CXCR2 (1.00) | CXCR2CX3CR1HTR1B | |
| SCHEMBL842971 | 0.83 | CXCR2 (0.84) | CXCR2CX3CR1HTR1B | |
| SCHEMBL840845 | 0.80 | CXCR2 (0.70) | CXCR2CX3CR1HTR1BMETAP2GAA | |
| SCHEMBL6704358 | 0.67 | CXCR2 (0.80) | CXCR2CX3CR1HTR1B | |
| SCHEMBL6619610 | 0.66 | CXCR2 (0.69) | CXCR2CX3CR1HTR1B | |
| SCHEMBL841858 | 0.65 | CXCR2 (0.74) | CXCR2CX3CR1HTR1B | |
| SCHEMBL841944 | 0.65 | CXCR2 (1.00) | CXCR2CX3CR1HTR1BKMT2A | |
| SCHEMBL841943 | 0.65 | CXCR2 (1.00) | CXCR2CX3CR1HTR1BKMT2A | |
| SCHEMBL5036023 | 0.64 | CXCR2 (0.70) | CXCR2CX3CR1HTR1B | |
| SCHEMBL213765 | 0.64 | CXCR2 (1.00) | CXCR2CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222195-B1 | NOVEL THIAZOLO(4,5-D)PYRIMIDINE COMPOUNDS | ASTRAZENECA UK LTD (GB) | 2004-01-14 | — | — | EP | claimed |