Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.60 |
| ▸ | CA1 | P00915 | 4/20 | 0.60 |
| ▸ | CA2 | P00918 | 4/20 | 0.60 |
| ▸ | CA9 | Q16790 | 4/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18017490 | 0.81 | CA12 (0.56) | CA12CA1CA2CA9MAPT | |
| SCHEMBL30894812 | 0.80 | KMT2A (0.46) | CA12CA1CA2CA9CASP1 | |
| SCHEMBL15750734 | 0.80 | CA12 (0.55) | CA12CA1CA2CA9KMT2A | |
| SCHEMBL26424817 | 0.79 | CA12 (0.53) | CA12CA1CA2CA9CASP1 | |
| SCHEMBL23928504 | 0.79 | CA12 (0.75) | CA12CA1CA2CA9MAPT | |
| SCHEMBL4319645 | 0.77 | MAPT (0.48) | CA12CA1CA2CA9MAPT | |
| SCHEMBL17385337 | 0.77 | MAPT (0.48) | CA12CA1CA2CA9MAPT | |
| SCHEMBL11606707 | 0.75 | CHEK1 (0.47) | CA12CA1CA2CA9MAPT | |
| SCHEMBL11379771 | 0.74 | MAPT (0.43) | MAPTPOLBSMN1; SMN2 | |
| SCHEMBL4261672 | 0.74 | POLB (0.46) | CA12CA1CA2CA9CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436265-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1436265-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003072541-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-04 | — | — | WO | disclosed |