Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584923 | 0.77 | CYP4F2 (0.45) | TDP1MAPTCYP4F2CYP4A11TSHR | |
| SCHEMBL14033827 | 0.75 | KMT2A (0.46) | TDP1MAPTTSHRKMT2A | |
| SCHEMBL8914213 | 0.73 | CYP4F2 (0.51) | TDP1MAPTCYP4F2CYP4A11TSHR | |
| SCHEMBL10438855 | 0.70 | CYP4F2 (0.58) | TDP1MAPTCYP4F2CYP4A11CA12 | |
| SCHEMBL8582152 | 0.69 | TDP1 (0.57) | TDP1CYP4F2CYP4A11CA12CA7 | |
| SCHEMBL38995 | 0.69 | TDP1 (0.56) | TDP1CYP4F2CYP4A11CA12CA7 | |
| SCHEMBL4764323 | 0.69 | CA12 (0.40) | PTGER1CA12CA9 | |
| SCHEMBL6541115 | 0.69 | KMT2A (0.57) | MAPTCA9TSHRKMT2A | |
| SCHEMBL12955273 | 0.69 | CYP4F2 (0.43) | TDP1MAPTCYP4F2CYP4A11TSHR | |
| SCHEMBL28216116 | 0.69 | TSHR (0.44) | PTGER1MAPTCYP4F2CYP4A11TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395571-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | Shire Biochem Inc. (CA) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002100846-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | SHIRE BIOCHEM INC. (CA) | 2002-12-19 | — | — | WO | disclosed |