Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8582970 | 0.87 | TDP1 (0.55) | TDP1CA12CA7CA14CA9 | |
| SCHEMBL38995 | 0.76 | TDP1 (0.56) | TDP1CA12CA7CA14CA9 | |
| SCHEMBL10438855 | 0.74 | CYP4F2 (0.58) | TDP1CA12CA7CA14CA9 | |
| SCHEMBL8579328 | 0.74 | APEX1 (0.46) | TDP1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL18802064 | 0.70 | CYP4F2 (0.57) | TDP1CA12CA7CA14CA9 | |
| SCHEMBL6617740 | 0.69 | TDP1 (0.49) | TDP1CA12CA7CA14CA9 | |
| SCHEMBL29852765 | 0.69 | NPC1 (0.52) | TDP1CA12CA7CA14TSHR | |
| SCHEMBL6240139 | 0.69 | KDM4E (0.50) | TDP1CA12CA7CA14CA9 | |
| SCHEMBL22954711 | 0.69 | CYP4F2 (0.56) | TDP1CA12CA7CA14CA9 | |
| SCHEMBL8914213 | 0.69 | CYP4F2 (0.51) | TDP1TSHRALDH1A1CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756549-A | RENIN INHIBITORS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |