Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616878 | 0.97 | KMT2A (0.38) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6617610 | 0.94 | KMT2A (0.40) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6617446 | 0.91 | CYP3A4 (0.39) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6618192 | 0.91 | NAMPT (0.36) | KMT2AMEN1ASAH1ROCK2NPC1 | |
| SCHEMBL6620809 | 0.90 | CHRNE (0.38) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6602660 | 0.90 | TERT (0.36) | KMT2AMEN1ASAH1ROCK2NPC1 | |
| SCHEMBL6619894 | 0.89 | KMT2A (0.39) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6616492 | 0.88 | HRH3 (0.38) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6619302 | 0.88 | MAPK14 (0.36) | KMT2AMEN1GAAASAH1ROCK2 | |
| SCHEMBL6616453 | 0.88 | KMT2A (0.36) | KMT2AMEN1CYP1A2CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |