Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.37 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.36 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.36 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614980 | 0.97 | CNR1 (0.42) | CNR1EPHX2ABL1SRCACKR3 | |
| SCHEMBL6634119 | 0.92 | CNR1 (0.42) | CNR1EPHX2NAMPTDPP4KCNJ6 | |
| SCHEMBL6621094 | 0.92 | PPARG (0.43) | CNR1KCNJ6KCNJ5KCNJ3MAPT | |
| SCHEMBL6603314 | 0.92 | PPARG (0.40) | CNR1ACKR3SENP5SENP2SENP1 | |
| SCHEMBL6618278 | 0.91 | MEN1 (0.45) | ACKR3SENP5SENP2SENP1MAPT | |
| SCHEMBL6617364 | 0.91 | CNR1 (0.42) | CNR1EPHX2ACKR3NAMPTDPP4 | |
| SCHEMBL6616448 | 0.90 | EPHX2 (0.40) | CNR1EPHX2ACKR3MAPTPKM | |
| SCHEMBL6618658 | 0.89 | PPARG (0.44) | CNR1KCNJ6KCNJ5KCNJ3MAPT | |
| SCHEMBL6617490 | 0.89 | PPARG (0.41) | CNR1ACKR3KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL6616412 | 0.89 | MAPT (0.41) | CNR1EPHX2ACKR3NAMPTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |