Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.37 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.36 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.36 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617385 | 0.92 | LMNA (0.39) | MEN1KMT2AHPGDMAPTCRACR2A | |
| SCHEMBL6603314 | 0.92 | PPARG (0.40) | PPARGKCNK3KCNK9ACKR3HPGD | |
| SCHEMBL6618100 | 0.91 | CNR1 (0.41) | MEN1KMT2AACKR3MAPTSENP5 | |
| SCHEMBL6616448 | 0.90 | EPHX2 (0.40) | PPARGACKR3HPGDMAPTKDM4E | |
| SCHEMBL6617490 | 0.89 | PPARG (0.41) | PPARGKCNK3KCNK9ACKR3MAPT | |
| SCHEMBL6615270 | 0.88 | CRACR2A (0.44) | MEN1KMT2APPARGKCNK3KCNK9 | |
| SCHEMBL6621094 | 0.88 | PPARG (0.43) | MEN1KMT2APPARGMAPTALDH1A1 | |
| SCHEMBL6614980 | 0.88 | CNR1 (0.42) | MEN1KMT2AACKR3MAPTSENP5 | |
| SCHEMBL6617337 | 0.87 | CNR1 (0.39) | ACKR3HPGDMAPTKDM4EALDH1A1 | |
| SCHEMBL6617735 | 0.87 | PKM (0.42) | MAPTCHRM5CHRM1CHRM3PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |