Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406324 | 0.86 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR2C | |
| SCHEMBL6619041 | 0.86 | ELANE (0.43) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR2C | |
| SCHEMBL6621891 | 0.86 | ELANE (0.43) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR2C | |
| SCHEMBL6624131 | 0.85 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR2C | |
| SCHEMBL6617554 | 0.83 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR2C | |
| SCHEMBL6618031 | 0.83 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR2C | |
| SCHEMBL7989218 | 0.83 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR2C | |
| SCHEMBL6619994 | 0.83 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR2C | |
| SCHEMBL6620544 | 0.83 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR2C | |
| SCHEMBL8132883 | 0.78 | PLA2G2A (0.37) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891362-B1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LTD (GB) | 2004-03-17 | — | — | EP | disclosed |
| US-6215002-B1 | CYCLIZATION, DEBLOCKING, DEPROTECTION, SULFONATION, CONDENSATION, AMIDATION; ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | GLAXO WELLCOME INC. | 2001-04-10 | — | — | US | disclosed |
| US-5994344-A | BRONCHITIS THERAPY | GLAXO WELLCOME INC. (US) | 1999-11-30 | — | — | US | disclosed |