SCHEMBL6618622

SCHEMBL6618622

Cc1cc(C#N)ccc1OCC1CO1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.57
GLA P06280 1/20 0.57
SSTR4 P31391 1/20 0.47
MRGPRX4 Q96LA9 1/20 0.46
TDP1 Q9NUW8 1/20 0.45
VDR P11473 1/20 0.44
TP53 P04637 3/20 0.44
TSHR P16473 3/20 0.44
HIF1A Q16665 2/20 0.44
CYP3A4 P08684 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MAPT P10636 2/20 0.43
HPGD P15428 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
CYP1A2 P05177 1/20 0.43
PPARG P37231 1/20 0.43
DRD4 P21917 1/20 0.42
PKM P14618 2/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26750381 0.89 ALDH1A1 (0.58) ALDH1A1GLASSTR4MRGPRX4TDP1
SCHEMBL11761868 0.85 AR (0.47) ALDH1A1GLATDP1TP53TSHR
SCHEMBL11749561 0.85 AR (0.50) ALDH1A1GLATDP1TP53TSHR
SCHEMBL28227853 0.83 ALDH1A1 (0.44) ALDH1A1GLASSTR4TDP1TP53
SCHEMBL21254360 0.82 SLC6A4 (0.57) SSTR4DRD4
SCHEMBL22134582 0.81 ALDH1A1 (0.63) ALDH1A1GLATDP1VDRTP53
SCHEMBL7953345 0.80 ALDH1A1 (0.64) ALDH1A1GLATDP1VDRTP53
SCHEMBL262508 0.80 ALDH1A1 (0.64) ALDH1A1GLATDP1VDRTP53
SCHEMBL7953349 0.80 ALDH1A1 (0.64) ALDH1A1GLATDP1VDRTP53
SCHEMBL24328865 0.80 ALDH1A1 (0.44) ALDH1A1GLASSTR4TDP1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047695-B1 NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS ASTRAZENECA AB (SE) 2004-03-17 EP disclosed
US-6291475-B1 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES ASTRAZENECA AB (SE) 2001-09-18 US disclosed
EP-1047695-A1 NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS AstraZeneca AB (SE) 2000-11-02 EP disclosed
WO-1999031100-A1 NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS ASTRAZENECA AB (SE) 1999-06-24 WO disclosed
US-3961071-A CARDIOVASCULAR DISORDERS, 1-PHENOXY-2-HYDROXY-3-TERT-BUTYLAMINO PROPANES BOEHRINGER INGELHEIM GMBH (DT) 1976-06-01 US disclosed