Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.38 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052709 | 0.90 | PDGFRB (0.38) | PDGFRBPDGFRAKITFLT3GRIN2B | |
| SCHEMBL6615006 | 0.77 | PDGFRB (0.41) | PDGFRBPDGFRAKITFLT3GRIN2B | |
| SCHEMBL8887646 | 0.75 | NPC1 (0.56) | PDGFRBPDGFRAKITFLT3GRIN2B | |
| SCHEMBL8499837 | 0.75 | PDGFRB (0.53) | PDGFRBPDGFRAGRIN2BGRIN1RAB9A | |
| SCHEMBL6618710 | 0.74 | PDGFRB (0.40) | PDGFRBPDGFRAKITFLT3RAB9A | |
| SCHEMBL8500901 | 0.74 | PDGFRB (0.71) | PDGFRBPDGFRARAB9ANPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8563702 | 0.74 | PDGFRB (0.52) | PDGFRBPDGFRAGRIN2BGRIN1RAB9A | |
| Hydrochloric Acid SCHEMBL8562915 | 0.73 | PDGFRB (0.69) | PDGFRBPDGFRARAB9ANPC1ALDH1A1 | |
| SCHEMBL9132288 | 0.71 | PDGFRB (0.40) | PDGFRBPDGFRARAB9ANPC1FGFR3 | |
| SCHEMBL6617109 | 0.71 | PDGFRB (0.40) | PDGFRBPDGFRARAB9ANPC1FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |