Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619205 | 0.90 | PDGFRB (0.41) | PDGFRBKITFLT3FGFR3KDR | |
| SCHEMBL6615006 | 0.90 | PDGFRB (0.41) | PDGFRBKITFLT3FGFR3KDR | |
| SCHEMBL9053687 | 0.73 | PDGFRB (0.43) | PDGFRBKITFLT3FGFR3KDR | |
| SCHEMBL8103024 | 0.68 | FGFR3 (0.37) | PDGFRBKITFLT3FGFR3KDR | |
| SCHEMBL8887646 | 0.68 | NPC1 (0.56) | PDGFRBKITFLT3KDRPDGFRA | |
| SCHEMBL8499837 | 0.67 | PDGFRB (0.53) | PDGFRBPDGFRAGRIN2BGRIN1ALDH1A1 | |
| SCHEMBL6616898 | 0.67 | PDGFRB (0.40) | PDGFRBKITFLT3FGFR3KDR | |
| SCHEMBL6618710 | 0.67 | PDGFRB (0.40) | PDGFRBKITFLT3FGFR3KDR | |
| SCHEMBL8500901 | 0.67 | PDGFRB (0.71) | PDGFRBPDGFRAALDH1A1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL8563702 | 0.66 | PDGFRB (0.52) | PDGFRBPDGFRAGRIN2BGRIN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |