Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 19/20 | 0.57 |
| ▸ | HTR1B | P28222 | 19/20 | 0.57 |
| ▸ | HTR1A | P08908 | 17/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | HTR1F | P30939 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | HTR5A | P47898 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR1E | P28566 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206483 | 0.86 | HTR1D (0.60) | HTR1DHTR1BHTR1A | |
| SCHEMBL5213858 | 0.84 | HTR1D (0.62) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL5207182 | 0.83 | HTR1D (0.71) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL5205998 | 0.81 | HTR1D (0.59) | HTR1DHTR1BHTR1A | |
| SCHEMBL5211773 | 0.80 | HTR1D (0.75) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL6617056 | 0.78 | HTR1A (0.75) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL6616886 | 0.78 | HTR1A (0.64) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL5207534 | 0.77 | HTR1A (0.58) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL6615695 | 0.77 | HTR1A (0.73) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL6398931 | 0.76 | HTR1A (0.67) | HTR1DHTR1BHTR1AADRB2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480972-A2 | COMPOUNDS POSSESSING AFFINITY AT 5HT1-TYPE RECEPTORS AND USE THEREOF IN THERAPY OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003068760-A2 | COMPOUNDS POSSESSING AFFINITY AT 5HT1-TYPE RECEPTORS AND USE THEREOF IN THERAPY OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |