Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620986 | 0.91 | ABCB1 (0.56) | NOX1ABCB1ALOX5PTPN1MAPT | |
| SCHEMBL6625154 | 0.89 | ABCB1 (0.69) | NOX1ABCB1ALOX5PTPN1MAPT | |
| SCHEMBL6621640 | 0.86 | ABCB1 (0.57) | NOX1ABCB1ALOX5PTPN1MAPT | |
| SCHEMBL6608693 | 0.86 | NOX1 (0.62) | NOX1ABCB1ALOX5PTPN1MAPT | |
| SCHEMBL6622165 | 0.86 | NOX1 (0.62) | NOX1ABCB1ALOX5PTPN1MAPT | |
| SCHEMBL6621400 | 0.84 | NOX1 (0.61) | NOX1ABCB1ALOX5PTPN1MAPT | |
| SCHEMBL13679675 | 0.83 | NOX1 (0.51) | NOX1ABCB1ALOX5PTPN1MAPT | |
| SCHEMBL6619898 | 0.83 | NOX1 (0.58) | NOX1ABCB1ALOX5PTPN1MAPT | |
| SCHEMBL3828912 | 0.82 | ABCB1 (0.69) | NOX1ABCB1ALOX5PTPN1MAPT | |
| SCHEMBL6606552 | 0.82 | NOX1 (0.57) | NOX1ABCB1ALOX5PTPN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-B1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | TAIJI BIOMEDICAL INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-0999835-A4 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORP (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0999835-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | Ontogen Corporation (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002155-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORPORATION (US) | 1999-01-21 | — | — | WO | disclosed |