Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | GCGR | P47871 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | FRK | P42685 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622165 | 0.90 | NOX1 (0.62) | NOX1ALOX5ABCB1PTPN1MAPT | |
| SCHEMBL6608693 | 0.85 | NOX1 (0.62) | NOX1ALOX5ABCB1PTPN1MAPT | |
| SCHEMBL6625154 | 0.83 | ABCB1 (0.69) | NOX1ALOX5ABCB1PTPN1MAPT | |
| SCHEMBL6619832 | 0.83 | NOX1 (0.60) | NOX1ALOX5ABCB1PTPN1MAPT | |
| SCHEMBL6606552 | 0.81 | NOX1 (0.57) | NOX1ALOX5ABCB1PTPN1MAPT | |
| SCHEMBL6621640 | 0.81 | ABCB1 (0.57) | NOX1ALOX5ABCB1PTPN1MAPT | |
| SCHEMBL6620986 | 0.79 | ABCB1 (0.56) | NOX1ALOX5ABCB1PTPN1MAPT | |
| SCHEMBL3828912 | 0.77 | ABCB1 (0.69) | NOX1ALOX5ABCB1PTPN1MAPT | |
| SCHEMBL13679687 | 0.77 | NOX1 (0.61) | NOX1ALOX5ABCB1PTPN1MAPT | |
| SCHEMBL13679702 | 0.77 | PTPN1 (0.72) | NOX1ALOX5PTPN1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-A4 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORP (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0999835-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | Ontogen Corporation (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002155-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORPORATION (US) | 1999-01-21 | — | — | WO | disclosed |