Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216424 | 0.87 | SYK (0.61) | SYKMAPTATMPPARACTSS | |
| SCHEMBL6936043 | 0.87 | SYK (0.61) | SYKMAPTATMPPARACTSS | |
| SCHEMBL3911384 | 0.86 | SYK (0.70) | SYKMAPTATMPPARACTSS | |
| SCHEMBL6208266 | 0.85 | SYK (0.57) | SYKMAPTATMPPARACTSS | |
| SCHEMBL23538215 | 0.85 | SYK (0.56) | SYKPPARACTSSFOLH1CTSK | |
| SCHEMBL203720 | 0.85 | PPARA (0.56) | SYKMAPTPPARACTSSFOLH1 | |
| SCHEMBL957159 | 0.85 | PPARA (0.56) | SYKMAPTPPARACTSSFOLH1 | |
| SCHEMBL2707177 | 0.85 | PPARA (0.56) | SYKMAPTPPARACTSSFOLH1 | |
| SCHEMBL5970914 | 0.85 | SYK (0.56) | SYKPPARACTSSFOLH1CTSK | |
| SCHEMBL45541 | 0.85 | SYK (0.56) | SYKPPARACTSSFOLH1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884058-A | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | 阿奇克斯制药公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-107257803-A | Polymyxins antiseptic for treating bacterium infection | 盟科医药技术公司（开曼群岛） | 2017-10-17 | — | — | CN | disclosed |
| EP-0891362-B1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LTD (GB) | 2004-03-17 | — | — | EP | disclosed |
| US-6215002-B1 | CYCLIZATION, DEBLOCKING, DEPROTECTION, SULFONATION, CONDENSATION, AMIDATION; ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | GLAXO WELLCOME INC. | 2001-04-10 | — | — | US | disclosed |
| US-6057457-A | ENZYME INHIBITORS FOR PROTEASE OR ENZYMES OF HYDROLYSIS | GLAXO WELLCOME INC. (US) | 2000-05-02 | — | — | US | disclosed |
| US-5994344-A | BRONCHITIS THERAPY | GLAXO WELLCOME INC. (US) | 1999-11-30 | — | — | US | disclosed |